Dr Jothydev interviewed by Dr Indrababu
Exenatide belongs to a new class of anti diabetic medications namely Incretin mimetics. Incretins potentiate meal-induced insulin production and secretion by the beta-cells and lower the blood glucose level in the presence of hyperglycaemia. Exenatide is derived from Extendin-4 found in the saliva of Gila monster (Heloderma suspectum) a giant lizard found in some parts of the Americas and Mexico.
This is the only injection other than insulin now available for the treatment of diabetes. Exendin-4 might also have direct effects on beta-cell neogenesis that are independent of insulin demand. The root of administration is subcutaneous (eg 5 mcg/bd). Exanetide is known by the name Byetta and was approved by US -FDA in April 2005.This drug is expected to hit the Indian market by 2007, the main limiting factor being the high cost.
|
Incretins, DPP-4 inhibitors- Video |
|
|
|
|