Abstract J. Kesavadev, S. Balakrishnan, S. Ahammed, S. Jothydev Jothydev's Diabetes and Research Center, Trivandrum, India Objectives: To evaluate improvement in symptoms of sexual dysfunction and peripheral neuropathy in T2DM subjects on insulin pump. Research design and method: Adults (n=56);mean age of 54 with insulin treated T2DM (mean duration 15 years), on basal bolus regimen using long acting plus rapid acting analogs and later switched to, and continued on CSII for minimum of 6 months were selected from an electronic database, DTMS (Diabetes Tele Management System). Treatment satisfaction and quality of life was assessed using a questionnaire adapted from Peyrot Rubin quality of life scale. Results: Significant improvement with sexual dysfunction was noted by 83% of pumpers while using CSII (23% had mild improvement, 43% moderate improvement and 17% marked improvement). 87% of pumpers noted improvement in peripheral neuropathic pain (26% had mild improvement, 48% had moderate improvement and 13% had marked improvement). Overall 95% of pumpers were satisfied with insulin pump. Conclusion: Patients with sexual dysfunction and painful peripheral neuropathy reported improvement in symptoms, statistically significant enough to strongly recommend the use of insulin pumps in select T2DM patients. Symptomatic improvement is accomplished not at the expense of increased insulin dose and weight gain. While selecting patients, affordability alone should not be the yard stick whereas learning skills and motivation should be the core deciding factors